Second Stage: During

Advance the treatment of stroke and neurological conditions through computational surgical simulations and medical device development.

Research Projects

EMBOLISE: Embolization of the Middle Meningeal Artery with ONYXTM Liquid Embolic System (LES) In the Treatment of Subacute and Chronic Subdural Hematoma

The study is a prospective, multi-center, randomized, interventional, open label, controlled medical device clinical study, sponsored by Medtronic, evaluating the performance of the Onyx™ LES for MMA embolization for patients with symptomatic subacute or chronic subdural hematoma (SDH). The Onyx™ LES for embolization of MMA is investigational in the US. The objective of this Medtronic-sponsored study is to evaluate the safety and effectiveness of Onyx™ LES embolization of the middle meningeal artery (MMA) as adjunct to conventional treatment (surgery or observation) for symptomatic subacute or chronic subdural hematoma. Patients who are diagnosed with subacute and chronic subdural hematoma will be enrolled in this study.  

MIND: A Prospective, Multicenter Study of Artemis a Minimally Invasive Neuro Evacuation Device, in the Removal of Intracerebral Hemorrhage

MIND, sponsored by Penumbra Inc., compares the safety and efficacy of minimally invasive endoscopic surgical treatment with the Apollo / Artemis Neuro Evacuation Device for supratentorial intracerebral hemorrhage to standard medical management. The expectation is that patients treated with the minimally invasive Artemis Device have better outcome as demonstrated by their surveyed quality of life. Patients diagnosed with intracerebral hemorrhage will be enrolled in the study. 

INVEST Feasibility: A Single Arm, Feasibility Study of Minimally Invasive Endoscopic Surgical Treatment with Apollo/Artemis for Supratentorial Intracerebral Hemorrhage

INVEST Feasibility is a Mount Sinai physician led, multicenter single-arm feasibility study that intends to provide an assessment of enrollment and follow-up feasibility for patients who present with a supratentorial intracerebral hemorrhage (ICH) and are being treated with the Apollo or Artemis Minimally Invasive Surgical Treatment (MIES) through neurological and functional assessments. Patients who are unable to be enrolled in the feasibility study are referred to the INVEST Registry study, where patients are only responsible for completing the assessments and are not treated with the Apollo or Artemis MIES. 

INVEST Registry: Minimally Invasive Endoscopic Surgical Treatment with Apollo / Artemis in Patients with Brain Hemorrhage: A Prospective Multicenter Registry

As the sister study to Mount Sinai’s INVEST Feasibility study, the INVEST Registry is a prospective, multicenter, single-arm, registry of patients with brain hemorrhages that either received the Apollo / Artemis Minimally Invasive Surgical Treatment (MIES) or who did not qualify for the concurrent INVEST Feasibility study. The primary objective of this registry is to provide additional safety, technical outcomes, and clinical outcomes data for MIES treatment with Apollo / Artemis for the evacuation of the supratentorial brain hemorrhage. 

Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor (OPEN-UP)

Working in tandem with Barrow Neurological Institute/Dignity Health, this study aims to determine whether dural venous sinus stenting is as safe and effective as cerebral spinal fluid (CSF) shunting in halting or improving moderate-to-severe visual loss in patients with idiopathic intracranial hypertension (IIH). Patients diagnosed with intracranial hypertension as well as moderate to severe visual loss will be included.

Registry of Transradial Access for Angiography

In collaboration with the Medical University of South Carolina, we aim to create a multi-site registry to investigate surgical and clinical characteristics of transradial access angiography. The study objective is to showcase that the use of the radial artery outweighs that of the femoral artery due to the radial artery’s smaller size and faster healing time compared to the femoral artery. Patient population includes adult patients undergoing both interventional and diagnostic angiograms.  

Autologous Mitochondrial Transplant for Ischemic Stroke

We hypothesize that by injecting healthy mitochondria into an artery in the brain that supplies tissue that is damaged from an ischemic stroke, the healthy mitochondria will be incorporated into the damaged brain cells and limit or prevent further damage, and may even restore function to damaged brain. The objective of this study is to learn if autologous mitochondrial transplantation, performed during mechanical thrombectomy, is safe for people. This will be a “first in human” study and the University of Washington will be the first institution to study this treatment in people. 

In vitro medical device testing

Our lab has developed a proving ground for newly developed endovascular medical devices. We are able to treat 3D–printed models of common cerebrovascular diseases (such as aneurysms or arteriovenous malformations) with medical devices the same way they would be used in surgery. We then use a suite of benchtop and computational methods to test the efficacy and safety of these devices. This suite includes computational fluid dynamics, particle image velocimetry, microtomographic imaging, and genetic testing of models lined with vascular cells.  

Intra-arterial chemotherapy for the treatment of severe head and neck cancer

We aim to explore an alternative chemotherapy delivery mechanism for patients with advanced head and neck cancers who have exhausted their treatment options. Currently chemotherapy for head and neck cancers is delivered through veins and must pass through various different organ systems prior to reaching the intended target. By offering treatment through arteries, we can directly target the vessels that feed the tumor and selectively deliver chemotherapy only where it is needed. 

Support the SANS Center in discovering ways to understand, treat, and prevent stroke, cerebrovascular disease, and other neurological disorders​

Come Meet Us Up Close

Symptomatic Subacute chronic Subdural Hematoma

EMBOLISE: Embolization of the Middle Meningeal Artery with ONYX Liquid Embolic system (LES) In the Treatment of Subacute and Chronic Subdural Hematoma

Intracerebral Hemorrhage

MIND: A Prospective, Multicenter Study of Artemis a Minimally Invasive Neuro Evacuation Device, in the Removal of Intracerebral Hemorrhage

Supratentorial Intracerebral Hemorrhage

INVEST Feasibility: A Single Arm, Feasibility Study of Minimally Invasive Endoscopic Surgical Treatment with Apollo/Artemis for Supratentorial Intracerebral Homorrhage (ICH)

Brain Hemorrhage

INVEST Registry: Minimally Invasive Endoscopic Surgical Treatment with Apollo/Artemis in Patients with Brian Hemorrhage: A Prospective Multicenter Registry

Idiopathic Intracranial Hypertension

Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor

disease name

Registry of Transradial Access for Angiography

Ischemic Stroke

Autologous Mitochondrial Transplant for Ischemic Stroke

Anuerysms

In vitro Medical Device Testing

Head and Neck Cancer

Intra-arterial Chemotherapy for the Treatment of Severe Head and Neck Cancer